If you like to use aliases, for example:

alias du="du -sh"

But time to time you want to bypass the alias:

'du'

but you already are at the end of a long command line

du file1 file2 file4 file5 folder1 folder2| #My cursor is the pipe

And your are too lazy to do home-quote-rightarrow-rightarrow-quote

'du' file1 file2...

You can just keep the single quotes to bypass the alias at the beginning:

''du file1 file2 ...